Hotline:400-820-3792Inhibitors ? ScreeningLibraries ? Proteinswww.MedChemESGC0946TFACat.No.:HY-15650A分子式: C??H??BrF?N?O?分子量: 732.59作用靶點: HistoneMethyltransferase作用通路: Epigenetics儲存方式: PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY生物活性SGC0946TFA是一種選擇性的DOT1L抑制劑，其IC50值為0.3nM。SGC0946TFA可通過抑制DOT1L，誘導(dǎo)癌細胞G1期停滯，以及抑制細胞的自我更新和轉(zhuǎn)移潛力，并誘導(dǎo)細胞分化。SGC0946TFA可用于白血病和乳腺癌等腫瘤的研究，也可作為探針以進一步研究DOT1L在正常和病變細胞中的細胞機制。IC50&TargetDOT1L0.3nM(IC50)客戶使用本產(chǎn)品發(fā)表的科研文獻MolCell.2021Oct7;81(19):4076-4090.e8.SciAdv.2023Jun2;9(22):eadc9273.Oncogenesis.2021Jul12;10(7):48.Elife.2020Oct1;9:e57858.MolCarcinog.2023May5.Seemorecustomervalidationsonwww.MedChemEREFERENCESZhangL,etal.InhibitionofhistoneH3K79methylationselectivelyinhibitsproliferation,self-renewalandmetastaticpotentialofbreastcancer.Oncotarget.2014Nov15;5(21):10665-77.ZhangX,etal.Prognosticandtherapeuticvalueofdisruptoroftelomericsilencing-1-like(DOT1L)expressioninpatientswithovariancancer.JHematolOncol.2017Jan23;10(1):29.1/2 MasterofBioactiveMolecules—您身邊的抑制劑大師www.MedChemE[3].YuW,etal.CatalyticsiteremodellingoftheDOT1Lmethyltransferasebyselectiveinhibitors.NatCommun.2012;3:1288.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792Fax:021-