Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemEAntimicrobialagent-6Cat.No.:HY-151400分?式:C??H??N??分?量:769.04作?靶點(diǎn):Bacterial作?通路:Anti-infection儲(chǔ)存?式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY?物活性Antimicrobialagent-6(Compound11)?種抗劑(antimicrobial)，對(duì)?蘭?陽(yáng)性和?蘭?性細(xì)的MIC范為4-8μg/mL。Antimicrobialagent-6也具有抗炎活性。體外研究Antimicrobialagent-6(Compound11)(0-256μg/mL;18-24h)showsantibacterialactivitywithgeometricmean(GM)valuesoftheMICsof5μg/mL[1].Antimicrobialagent-6showsminimumhemolyticconcentration(MHC)of>256μg/mL,thetherapeuticindexis102.4[1].Antimicrobialagent-6(5or20μg/mL;18h)effectivelyinhibitsthereleaseandexpressionofNOandTNF-αfromLPS-stimulatedRAW264.7cells[1].Antimicrobialagent-6isresistanttovariousphysiologicalsalts,humanserum,andproteases[1].CellViabilityAssay[1]CellLine:E.coli[KCTC1682],P.aeruginosa[KCTC1637],S.epidermidis[KCTC1917]andS.aureus[KCTC1621]Concentration:0-256μg/mLIncubationTime:18-24hResult:InhibitedbacterialgrowthwithMICsof8,4,4and4μg/mLagainstE.coli[KCTC1682],P.aeruginosa[KCTC1637],S.epidermidis[KCTC1917]andS.aureus[KCTC1621],respectively.RT-PCR[1]1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemECellLine:LPS-stimulatedRAW264.7macrophagesConcentration:5μg/mL(forNO/iNOS)and20μg/mL(forTNF-α)IncubationTime:18hResult:EffectivelyinhibitedtheproductionandexpressionofNOandTNF-αfromLPS-stimulatedRAW264.7cells.REFERENCES[1].DineshKumarS,etal.Cationic,amphipathicsmallmoleculesbasedonatriazine-piperazine-triazinescaffoldasanewclassofantimicrobialagents.EurJMedChem.2022Sep8;243:114747.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-37