抗抑郁藥物及其研究方法的進(jìn)展_楊小瑩1（ANTIDEPRESSANTSANDRESEARCHMETHODSIN_YANGXIAOYING1）36YATIMAHALIAS，KHALIJAHAWANG，AHAMIDAHAD，我一個(gè)一個(gè)埃塔TIMITOTIC和細(xì)胞毒性FROMFISSISTIGMALANUGINOSUM查爾酮J。JNATPROD，1995,581160。37NICHOLASJLAWRENCE，DAVIDRENNISON，ALANTMCGOWN，等一等一個(gè)橙酮的全合成FROMUVARIA源分離噢，黃酮類化合物作為抗癌劑的研究J。BIOORGMED化學(xué)其中，2003,133759。38NORIYOSHINAKATAN，MOMOYOICHIMARU，MASATAKAMORIYASU，等對(duì)人早幼粒細(xì)胞白血病細(xì)胞凋亡誘導(dǎo)L粒BYC芐查爾酮類，UVARETIN，ISOUVARE錫和雙紫玉盤素J。BIOLPHARMBUL，2005,2883。39WUJH，WANGXH，YIYH，我再AGENTS54IAIDS埃塔。一個(gè)寶帳篷螞蟻縱橫混排查爾酮和黃酮的GENUSDESMOSJ。BIOORGMED化學(xué)快報(bào)，2003,131813。40PHANVANKIEM，CHAUVANMINH，HOANGTHANHHUONG，等一等AGAINSTNFATTRAN有抑制活性的酚類成分描述FROMDESMOSCHINENSISJ。拱醫(yī)藥研究，2005,281345。41MAYUNGAHHNKUNYA，HUGOWEENEN，DOROTHYHBRAY，等一等坦桑尼亞植物及其活性成分的抗瘧活性學(xué)生紫玉盤屬的研究J。PLANTAMED，1991,57341。42SHOKOYOKOYAMA，TADAHIROTAKEDA，HIROMITAKAHASH，我等一等脂質(zhì)過(guò)氧化與抗氧化作用3，5,7,4四羥基黃酮；原子FORCEMI直接觀察研究J。JOLEOSC，我2002,5163。在從番荔枝科和生物黃酮類化合物的研究進(jìn)展這些化合物的活性胡CHUNMEI1，2、五JIUHONG2（1。藥理學(xué)與毒理學(xué)研究所，中國(guó)科學(xué)院OFMILITARYMEDICAL，BEIJING100850；2。藥劑科，306HOSPITAL有限，北京100101，中國(guó)）摘要超過(guò)50個(gè)新的黃酮類化合物來(lái)自ANNONACEAE的報(bào)道在過(guò)去的二十年。在許多屬NONACEAE包含有STRUCTURALNOVELTY和廣泛的藥理活性的黃酮類化合物。由于一些藥理利益在這些化合物中，關(guān)于這個(gè)問(wèn)題的化學(xué)研究在幾十年中有了長(zhǎng)足的發(fā)展。這里的生物活性部分這些黃酮類化合物也進(jìn)行了簡(jiǎn)要討論。關(guān)鍵詞番荔枝科；黃酮類化合物；生物活性；ANTI腫瘤責(zé)任編輯戴暢收稿日期20061210基金項(xiàng)目江蘇省自然科學(xué)基金項(xiàng)目（BK2005149）；江蘇省中醫(yī)藥局中醫(yī)藥科研項(xiàng)目（H05074）；江蘇省教育廳自然科學(xué)基金項(xiàng)目（02KJB360002）通訊作者馬世平，TEL（025）85322594，郵件我SHIPINGMAHOTMAILCOM。抗抑郁藥物及其研究方法的進(jìn)展楊小瑩1，陳杰2，YANGXINMING2,MASHIPING11、DEPARTMENTOFPHARMACOLOGY,CHINESEMATERIAMEDICA,CHINAMEDICINEUNIVERSITY,JIANGSU210038,NANJING,CHINATHEQUALITYDEPARTMENT2GUANGDONGBIDIPHARMACEUTICALCOLTD,GUANGDONGKAIPING529331ABSTRACTTHEPREVENTIONANDTREATMENTOFDEPRESSIONHASATTRACTEDWORLDWIDEATTENTIONTHROUGHCONSULTINGRELEVANTLITERATURESATHOMEANDABROADINRECENTYEARSANDCOMBININGRELEVANTRESEARCHRESULTS,THETHECLASSIFICATIONOFANTIDEPRESSANTDRUGS,ESPECIALLYTHEEXTRACTSOFNATURALDRUGS,ACTIVEINGREDIENTSANDCHINESEHERBALMEDICINE,ISREVIEWEDANDREVIEWEDTHEPROGRESSOFTHEEXPERIMENTALMETHODANIMALMODELISSUMMARIZED,ANDTHECONSISTENCY,INADEQUACYANDCLINICALVALUEOFTHEEXPERIMENTALRESEARCHMETHODSCOMBINEDWITHCLINICALPRACTICEARESUMMARIZED770THIRTYSECONDVOLUME,NINTHISSUEINMAY2007,CHINESEJOURNALOFTRADITIONALCHINESEMEDICINE,CHINA,JOURNAL,OFCHINESEM,ATERIAM,EDICA,VOL32,ISSUE,9MAY,2007ANDOTHERASPECTSWEREANALYZEDANDDISCUSSEDDEPRESSIONNATURALDRUGSANIMALMODELSCLINICALEFFECTSCLCNOR2855DOCUMENTIDENTIFICATIONCODEAARTICLENUMBER10015302200709077005DEPRESSIONDEPRESSIONISCAUSEDBYAVARIETYOFCAUSESANDISCHARACTERIZEDBYMOODDISORDERSMAJORFEATURESOFTHESYNDROMEWITHTHEINTENSIFICATIONOFALLKINDSOFSTRESSFACTORS,THEINCIDENCEISPOSITIVEINTHERAPIDRISE,HIGHINCIDENCEANDDIFFICULTTOCUREBUTITSPATHOGENESISISVERYCOMPLEX,SOFARITHASNOTBEENELUCIDATEDFROMTHEEARLIESTMONOAMINEHYPOTHESISTOTHEHYPOTHALAMUSPITUITARYADRENALGLANDHPAAXISNEGATIVEFEEDBACKDYSREGULATION,ANDTHENCELLULARANDMOLECULARMECHANISMS,MAYBEASSOCIATEDWITHDEPRESSIONMORBIDITYRELATEDASTHEPATHOGENESISISRAISED,THEETIOLOGYOFDEPRESSIONISCLARIFIEDFURTHERENRICHTHEEXPERIMENTALRESEARCHMETHODS,BUTALSOFORTHEDEVELOPMENTOFSAFEANDEFFECTIVENEWDRUGSREFERTOCLEARDIRECTIONINRECENTYEARS,ESPECIALLYTHESTUDYOFANTIDEPRESSANTNATURALDRUGSHASMADEONEDEFINITEDEVELOPMENTPROVIDESAWIDERANGEOFDRUGSWITHHIGHEFFICACYANDLOWSIDEEFFECTSFOREGROUNDTHEAUTHORREVIEWEDTHEDOMESTICANDFOREIGNANTIDEPRESSANTDRUGSINRECENT5YEARSTHERESEARCHPROGRESSANDTHEPROGRESSOFRELATEDRESEARCHMETHODSARESUMMARIZED1ADVANCESINANTIDEPRESSANTDRUGSITSDEVELOPMENTANDDEVELOPMENTISANEWBREAKTHROUGHINTHETREATMENTOFDEPRESSION,ESPECIALLYNATURALDRUGSTHERESEARCHWILLBECOMETHENEWHOTSPOTANDTHEDEVELOPMENTTENDENCY11CHEMICALANTIDEPRESSANTNEWANTIDEPRESSANTDRUGSDEVELOPEDINRECENTYEARSINCLUDEBOTHDOPAMINEDAANDD2ARECEPTORFORPARTIALAGONISTAND5SEROTONIN1A5HT1ARECEPTORAGONISTACTIONINANIMALMODELTESTS,BIFEPRUNOXHASAGOODANTIDEPRESSANTEFFECTPHASEIIICLINICALSTUDYWASPERFORMED,1CORTICOTROPINRELEASINGHORMONECRHRECEPTORANTAGONISTANTALARMINCANREVERSETHEHPAAXISCHANGESINDUCEDBYCHRONICSTRESSTHECURATIVEEFFECTISEQUIVALENTTOTHATOFFLUOXETINE,2MELATONINRECEPTORAGONISTSAGOMELATINEAGOMELATINEFIRSTANTIDEPRESSANTTARGETSTARGETINGMELATONINHORMONERECEPTORSDRUGSAREAGONISTSOFTHEMELATONINRECEPTOR1ANDRECEPTOR2,AND5HT2CRECEPTORANTAGONISTS,THEEFFICACYOFTHISDRUG,ISCOMPARABLETOTHECURRENTLYUSEDSELECTIVESEROTONIN5INHIBITORSSSRISANDNOREPINEPHRINEREUPTAKEINHIBITORSSNRISPHASENEAR,BUTRARELY,THETYPICALADVERSEREACTIONSOFTHETWOPATIENTSWEREWELLTOLERATEDATPRESENT,SERVIERHASSUBMITTEDANAPPLICATIONFORREGISTRATIONOFTHEDRUGINTHEEUROPEANUNIONFORTREATMENTTREATADULTSWITHDEPRESSION,3,4ACCORDINGTOREPORTS,THEUNITEDSTATESSYNAPTICPHARMACEUTICALCOMPANYFOUND1NEW,POWERFULANTIDEPRESSANTWITHTARGETSOF1GPROTEINCOUPLEDRECEPTORSTHEANTIDEPRESSANTEFFECTISSIMILARTOTHATOFPROZAC,ANANTIDEPRESSANT,FLUOXETINE,ANDISNOTFEWGOODREACTIONS12ANTIDEPRESSANTNATURALDRUGS121ANTIDEPRESSANTCOMPONENT1211NOLDNER5RUTINOFFLAVONOIDSRUTINISHYPERICUMPERFORATUMANTIDEPRESSANTACTIVEINGREDIENTSLIYUNFENGAND6REPORTEDTOTALFLAVONOIDSOFCOTTONSEEDCTN1TOSHORTENTHEIMMOBILITYTIMEOFFORCEDSWIMMINGFSTANDTAILSUSPENSIONTSTINMICEANDMICE,SEROTONINACID5HTPENHANCED5INDUCEDHEADTWITCHESZHANGLIMING,ETAL,71NOVELANTIDEPRESSANTS,QUERCETIN,3O,APIGENIN,RUTINGLYCOSIDESCTN986THEEFFECTOFCTN986ONTHEPROLIFERATIONOFNEURALPRECURSORCELLSWASFOUNDINTHESEATHEPROLIFERATIONOFEQUINENEURALPRECURSORCELLS,ANDTHEACTIONANDACTIVATIONOF5HT1A,AREREGULATEDBYTHISPATHWAYCLOSELYRELATEDZHOULANLANETAL8REPORTED1SPECIESFROMBEAUVERIABASSIANABEAUVERIA,SPANOVELBIOACTIVESUBSTANCEEXTRACTEDFROMMETABOLITESMAINLYGLYCOSIDESANDKETONESTSTANDFSTIMMOBILITYTIMEINMICEWERESIGNIFICANTLYSHORTENEDTHEBRAINTISSUESOFMICEWEREHEAVY,ANDTHEACTIVITIESOFMITOCHONDRIALMONOAMINEOXIDASEMAOA,BWEREOBVIOUSANDSHOWEDACERTAINDOSEEFFECTRELATIONSHIP1212,LIGNANS,TAKAHIRO,N,ANDOTHER9STUDIESHAVESHOWNTHATTHEPOPULATIONISWELLSERVEDWATEREXTRACTOFSTEMANDLEAFOFGARDENMAGONOLIAOFFICINALISWASOBTAINEDINHUMANURINEBYMAGNOLOLMAGNOLOLANDMETABOLITETWOHYDROXYTWOMAGNOLOLDIHYDROXYDROMAGNOLOLINCOMPARISONWITHIMIPRAMINE,HONOKIOLANDMETABOLITETWOHYDROXYTWOHYDROGENWERETHICKINMICE,FSTWASFOUNDTOHAVEBOTHMAGNOLOLANDTWOHYDROXYTWOMAGNOLOLTHEMECHANISMOFANTIDEPRESSANTACTIONMAYBERELATEDTOTHEFUNCTIONOFYAMINOBUTYRICACIDGABAERGICOF1213ORGANICACIDS,XUY,ETC10STUDIESTURMERICCURCUMALONGACURCUMINCANSHORTENTHEIMMOBILITYTIMEOFRATFST,ANDCANPREVENTBILATERALOLFACTORYBULBDAMAGEMODELOBABNORMALBEHAVIORINRATSTAKEDAAND11REPORTEDTRADITIONALANTIDEPRESSANTSTHEWATEREXTRACTOFPERILLAFRUTESCENSPERILLAANDFRUTECENSCOULDOBVIOUSLYSHORTENTHEIMMOBILITYOFFSTINMICETIME,THEOBTAINEDROSMARINICACIDROSMARINIC,ACIDISTHEMAINANTIDEPRESSANTACTIVEINGREDIENTSLIYUNFENG121214OLIGOSACCHARIDEOFMORINDAOFFICINALISINULINTYPELOWTHEMECHANISMOFTHEANTIDEPRESSANTEFFECTOFGLYCANMONOMERONMICE,ANDITSPOSSIBLERELATIONSHIPWITHGODINCREASEDEXPRESSIONOFCELLULARTROPHICFACTORSRESULTINGININJURYTOCORTICOSTERONEINDUCEDNEURONSOFAPROTECTIVEEFFECT1215BENPROPERINESALEE13FROMPIPERLON,LONGPEPPERPEPPERGUMOBTAINEDFROMETHANOLICEXTRACTSOFFRUITSHASAMONOAMINEOXIDASETHEINHIBITORYEFFECTSOFMAOAANDMAOBONIC50WERE20,9,7,0,MMOL,RESPECTIVELYTHEINHIBITORYCONSTANTSKI,L1,19,0,/0,9,3,19,/0,5MMOLANDL1,ANDTHEINHIBITIONWASREVERSIBLE1216,CURCUMIN,XUYING,ANDOTHER14STUDIESHAVEFOUNDTHATCURCUMINCANREVERSEPROFITSTHEBODYTEMPERATUREOFMICEINDUCEDDECREASEINBLOOD,INCREASETHEHEADOFMICEINDUCEDBY5HTPASIGNIFICANTDECREASEINTHEBODYTEMPERATUREOFMICEINDUCEDBYHIGHDOSEAPOMORPHINEWASOBSERVEDTHECONTENTOF5SEROTONIN5HTINTHEBRAINOFMICEWENCAIXIAETAL15RESEARCHTABLESCURCUMINDERIVATIVEFM02HASGOODWATERSOLUBILITY,DOSE5,10MGKG1MICEHAVEBETTERANTIDEPRESSANTEFFECTSAFTERINTRAGASTRICADMINISTRATION1217GLYCOSIDESSUCHASPAN,YAND16REPORTEDTHATICARIINCANSHORTENFSTANDTSTIMMOBILITYTIMEAGAINSTFORCEDSWIMMINGINDUCESMONOAMINEOXIDASEACTIVITYINTHEBRAINANDTHEELEVATIONOFCORTICOTROPINRELEASINGFACTORCRFCONCENTRATIONINPLASMATHECONCENTRATIONOFMONOAMINETRANSMITTERSDECREASEDGUZHAOYANGETALREPORTEDDAIDZEIN,17,ACIDTHEANTIDEPRESSANTEFFECTOFSALTISCLOSELYRELATEDTODOSE,DURATIONOFADMINISTRATIONANDSEXOFMICETHEDIFFERENCEINTHECORRELATIONBETWEENMALEANDFEMALESEXMAYBERELATEDTOTHEFEMALESTIMULATIONOFDAIDZEINRELATEDTOTHEACTIONOFBIOTINCHENYAOAND18REPORTEDTHEANTIDEPRESSANTACTIVITYOFTOTALGLYCOSIDESOFCENTELLAASIATICAITISRELATEDTOTHEIMPROVEMENTOFHPAAXISFUNCTIONANDTHEINCREASEOFMONOAMINETRANSMITTERSMASUDAETAL19STUDYKAMISHOYOSANCANSIGNIFICANTLYREDUCETHEDESPAIRBEHAVIOROFMICEANDDETERMINETHEACTIVITYTHECONSTITUENTISOXYGENGLUCOSIDESTRUCTUREZHAOZHIYUANDOTHER20STUDIESHAVESHOWNTHATGLYCYRRHIZINCANIMPROVEINTHEDEPRESSIONMODEL,SYMPTOMSOFEUPHORIAMAYCONTRIBUTETODEPRESSIONBYIMPROVINGTHEBODY771THIRTYSECONDVOLUME,NINTHISSUEINMAY2007,CHINESEJOURNALOFTRADITIONALCHINESEMEDICINECHINAJOURNALOFCHINESEMATERIAMEDICAVOL32,ISSUE9MAY,2007SUPEROXIDEDISMUTASEACTIVITY,FREERADICALSWEREELIMINATED,LIPIDPEROXIDATIONWASPREVENTEDANDREDUCEDTHEFORMATIONOFMALONDIALDEHYDEISACHIEVED122SINGLEFLAVORCHINESEMEDICINE1221SANCHEZMATEO,C,CANDOTHERREPORTSOFTHEGENUSHYPERICUMAREREPORTEDBY21TWOSPECIESOFHYPERICUMHYPERICUM,CANARIENSEANDHGLANDULOSUMTHEMETHANOLEXTRACTSOFTHEUPPERPARTOFTHEGROUNDCANBESIGNIFICANTLYREDUCEDINTWOPARTSOFBUTANOLANDCHLOROFORMTHEIMMOBILITYTIMEOFSHORTMICEFST,H,GLANDULOSUMCHLOROFORMSITECANALSOBEANTAGONISTICBENZENEINDUCEDQUINOLIZINERESISTFORCIBLEDRAFTINGEYEDROPCHLOROFORMEXTRACTOFGLANDULOSUMHTHEEFFECTOFFSTONIMMOBILITYTIMEOFMICEWASSIMILARTOTHATOFIMIPRAMINEWANDEGUANGANDSOON22NEWSPAPERHSAIDHYPERICUMPERFORATUM,HYPERICUMSAMPSONIIHSAMPSONIIANDEVENTHEYANGTZEALICEHFABERI,3SPECIESOFHYPERICUMGROUPANDMEDICINALPLANTSOFHYPERICUMPERFORATUM,CANFSTANDTSTSHORTENEDTHEIMMOBILITYTIMEOFMICE,BUTTHEANTIALCOHOLEXTRACTOFHYPERICUMPERFORATUMLTHEEFFECTOFDEPRESSIONISOBVIOUSLYSTRONGERTHANTHATOFTHEYANGTZE1222,GINKGOBILOBA,SAKAKIBARAH,ETAL23REPORTEDETHANOLEXTRACTSFROMGINKGOBILOBALEAVES10,50,MG,KG1,INTRAGASTRICADMINISTRATIONOF14D,ORSINGLEABDOMINALCAVITY,50,100MGKG1CANSIGNIFICANTLYSHORTENTHEIMMOBILITYTIMEOFRATFSTANDMOUSETST1223,LICORICE,DHINGRA,D,ETC24REPORTEDLICORICEAQUEOUSEXTRACT150MGKG1SHORTENEDTHEIMMOBILITYTIMEOFMALEALBINOMICEINFSTANDTSTEXPERIMENTSTHEMECHANISMMAYBETHEINHIBITIONOFMONOAMINEOXIDASE1224SAGE,MOR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