Hotline:400-820-3792Inhibitors ? ScreeningLibraries ? Proteinswww.MedChemEPramipexoledihydrochloride(Standard)Cat.No.:HY-17355RCASNo.:104632-25-9分子式:C??H??Cl?N?S分子量:284.25作用靶點(diǎn):DopamineReceptor作用通路:GPCR/GProtein;NeuronalSignaling儲(chǔ)存方式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY生物活性 Pramipexole(dihydrochloride)(Standard)是Pramipexole(dihydrochloride)的分析標(biāo)準(zhǔn)品。本產(chǎn)品用于研究及分析應(yīng)用。Pramipexoledihydrochloride是一種選擇性的，具有血腦屏障(BBB)滲透性的D2型多巴胺受體(dopamineD2-typereceptor)激動(dòng)劑，對(duì)D2型受體、D2、D3、D4亞型受體的REFERENCESKvernmo,T.,etal.Areviewofthereceptor-bindingandpharmacokineticpropertiesofdopamineagonists.ClinTher,2006.28(8):p.1065-78.TakashiOkura,etal.Blood-brainbarriertransportofpramipexole,adopamineD2agonist.LifeSci.2007Apr3;80(17):1564-71.GinettaCollo,etal.RopiniroleandPramipexolePromoteStructuralPlasticityinHumaniPSC-DerivedDopaminergicNeuronsviaBDNFandmTORSignaling.NeuralPlast.2018;2018:4196961.PMCarvey,etal.Attenuationoflevodopa-inducedtoxicityinmesencephalicculturesbypramipexole.JNeuralTransm(Vienna).1997;104(2-3):209-28.SyedSuhailAndrabi,etal.Pramipexolepreventsischemiccelldeathviamitochondrialpathwaysinischemicstroke.DisModelMech.2019Aug1;12(8):dmm033860.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792Fax:0