Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemENrf2activator-20Cat.No.:HY-175217CASNo.:89883-16-9分?式:C?H?Br?O?分?量:360.83作?靶點(diǎn):Keap1-Nrf2作?通路:NF-κB儲(chǔ)存?式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY?物活性Nrf2activator-20?種具有抗炎抗氧化活性，強(qiáng)效的Nrf2激活劑。Nrf2activator-20通過?擾Keap1-Nrf2之間的相互作?來激活抗炎途徑，并且在體內(nèi)具有有益效果。SK2187可?于研究急性窘迫呼吸綜合征(ARDS)和缺?再灌注損傷[1]。體外研究Nrf2activator-20(CompoundAP9)(1μM,2h)stronglyinducestheNrf2pathwayinbothLPSstimulatedandnon-stimulatedRAWcells[1].WesternBlotAnalysis[1]CellLine:RAW264.7cellsConcentration:1μMIncubationTime:2hResult:InducednucleartranslocationofNrf2significantlywhileinducingHO-1expressionatnanomolarconcentrations.體內(nèi)研究Nrf2activator-20(CompoundAP9)(0.78mg/kg,i.p.,singledose)significantlyalleviatedtheliverinjuryinmiceintheliverischemia-reperfusioninjurymodel[1].Nrf2activator-20(0.78mg/kg,i.p.,singledose)alleviatethelunginjuryinthemicemodelinducedbyE.coli[1].AnimalModel:Warmliverischemia/reperfusioninjurymodelestablishedinC57BL/6Jmice(9-14weeks1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemEold,27g)[1]Dosage:0.78mg/kgAdministration:Intraperitonealinjection(i.p.),singledosepriortosurgeryResult:SignificantlyreducedplasmaALTandASTaswellashepatocellularinjury.AnimalModel:LunginjurymodelinducedbyE.colitreatmentestablishedin11–12weekoldmaleC57BL/6mice[1]Dosage:0.78mg/kgAdministration:Intraperitonealinjection(i.p.),singledoseResult:AbletoimproveoxygenationduringE.coli-inducedlunginjury.REFERENCES[1].LatreilleE,etal.Phenotypicscreeningininfluenza-infectedzebrafishidentifiesNrf2-mediatedcompoundprotectiveagainstischemia-reperfusioninjury.iScience.2025Jul4;28(8):113065.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-82