Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemEQuinacrine(Standard)Cat.No.:HY-13735RCASNo.:83-89-6分?式:C??H??ClN?O分?量:399.96作?靶點:Parasite;SodiumChannel;DNAStain;Apoptosis作?通路:Anti-infection;MembraneTransporter/IonChannel;CellCycle/DNADamage;Apoptosis儲存?式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY?物活性Quinacrine(Standard)Quinacrine的分析標(biāo)準(zhǔn)品。本產(chǎn)品?于研究及分析應(yīng)?。Quinacrine(Acriquine)是?種抗瘧疾和抗癌劑。Quinacrine還抑制?醛氧化酶(aldehydeoxidase)(IC50:3.3μM)。Quinacrine對核酸具有親和?，并對定細(xì)胞中的DNA和RNA染?(Ex/Em:436/525nm)。REFERENCES[1].VogtherrM,etal.AntimalarialdrugquinacrinebindstoC-terminalhelixofcellularprionprotein.JMedChem.2003Aug14;46(17):3563-4.[2].PrydeDC,etal.Aldehydeoxidase:anenzymeofemergingimportanceindrugdiscovery.JMedChem.2010Dec23;53(24):8441-60.[3].McNealET,etal.[3H]BatrachotoxininA20alpha-benzoatebindingtovoltage-sensitivesodiumchannels:arapidandquantitativeassayforlocalanestheticactivityinavarietyofdrugs.JMedChem.1985Mar;28(3):381-8.[4].CaroAA,etal.RoleofphospholipaseA2activationandcalciuminCYP2E1-dependenttoxicityinHepG2cells.JBiolChem.2003Sep5;278(36):33866-77.[5].AlAsmariAK,etal.Protectiveeffectofquinacrineagainstglycerol-inducedacutekidneyinjuryinrats.BMCNephrol.2017Jan28;18(1):41.[6].alKhaderA,etal.Quinacrineattenuatescyclosporine-inducednephrotoxicityinrats.Transplantation.1996Aug27;62(4):427-35.[7].WuX,etal.QuinacrineInhibitsCellGrowthandInducesApoptosisinHumanGastricCancerCellLineSGC-7901.CurrTherResClinExp.2012Feb;73(1-2):52-64.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;