Hotline:400-820-3792Inhibitors ? ScreeningLibraries ? Proteinswww.MedChemEPROTACHBeAgdegrader-1Cat.No.:HY-174856分子式:C??H??ClFN?O?S?分子量:990.6作用靶點(diǎn):PROTACs;HBV作用通路:PROTAC;Anti-infection儲(chǔ)存方式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY生物活性 PROTACHBeAgdegrader-1是一種針對(duì)HBeAg的PROTAC靶向降解劑。PROTACHBeAgdegrader-1能夠招募VHLE3連接酶，但降解乙肝病毒蛋白(HBeAg)的作用并不依賴于VHL的招募機(jī)制。PROTACHBeAgdegrader-1可降低分泌型和細(xì)胞內(nèi)HBeAg的水平。PROTACHBeAgdegrader-1可用于乙肝病毒(HBV)的研究[1]。(結(jié)構(gòu)：粉色：HBeAg配體(HY-174857)；Blue：CRBN連接酶配體(HY-125845)；黑色：連接子；E3配體-連接子偶聯(lián)物(HY-135045))IC50&TargetCereblon體外研究PROTACHBeAgdegrader-1(CompoundLH-3)(0.1-100μM,24h)decreaseslevelsofsecretedandintracellularHBeAginaconcentrationdependentmannerinHEK293THiBiT-HBeAg-Scells[1].PROTACHBeAgdegrader-1(10μM,24h)showsVHL-dependentdepletionofHBeAg,ratherthanVHLrecruitmentinHEK293THiBiT-HBeAg-Scells[1].PROTACHBeAgdegrader-1(10μM,6days)causesastrongreductioninHBcAginHepAD38cells[1].PROTACHBeAgdegrader-1(10μM,24h)iseffectiveatcurtailingT109IHBVproducedWTHBeAginHuh7cells[1].WesternBlotAnalysis[1]CellLine:HEK293T,HEK293TVHLKOcellsConcentration:10μMIncubationTime:24hResult:Showedstatisticallysignificant,albeitminor,rescueofsecretedHBeAglevelsin1/2 MasterofBioactiveMolecules—您身邊的抑制劑大師www.MedChemEHEK293TVHLKOcells.WesternBlotAnalysis[1]CellLine:HepAD38cellsConcentration:10μMIncubationTime:6daysResult:CausedastrongreductioninHBcAg.REFERENCESHalesLT,etal.VHL-independentdegradationofhepatitisBviruseantigen(HBeAg)byVHL-bindingchimericsmallmolecules.RSCMedChem.2025Mar28.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;