Hotline:400-820-3792Inhibitors ? ScreeningLibraries ? Proteinswww.MedChemEPerindopril(Standard)Cat.No.:HY-B0130RCASNo.:82834-16-0分子式:C??H??N?O?分子量:368.47作用靶點:Angiotensin-convertingEnzyme(ACE);NF-κB;STAT;Sirtuin作用通路:MetabolicEnzyme/Protease;NF-κB;JAK/STATSignaling;StemCell/Wnt;CellCycle/DNADamage;Epigenetics儲存方式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY生物活性Perindopril(Standard)是Perindopril的分析標(biāo)準(zhǔn)品。本產(chǎn)品用于研究及分析應(yīng)用。Perindopril(S-9490)是一種口服有效的長效血管緊張素轉(zhuǎn)換酶(ACE)抑制劑。Perindopril能夠抑制炎癥細(xì)胞流入和內(nèi)膜增厚，保存主動脈內(nèi)側(cè)彈性蛋白。Perindopril有效抑制大鼠模型中實驗性腹主動脈瘤(AAA)形成、降低肺動脈高壓大鼠的肺血管收縮。REFERENCESBhatSA,etal.AngiotensinreceptorblockademodulatesNFκBandSTAT3signalingandinhibitsglialactivationandneuroinflammationbetterthanangiotensin-convertingenzymeinhibition[J].Molecularneurobiology,2016,53:6950-6967.WeiX,etal.Combinationofperindoprilerbumineandhuangqi-danshendecoctionprotectsagainstchronickidneydiseaseviasirtuin3/mitochondrialdynamicspathway[J].Evidence-BasedComplementaryandAlternativeMedicine,2022,2022.AfonsoT,etal.Pharmacodynamicevaluationof4angiotensin‐convertingenzymeinhibitorsinhealthyadulthorses[J].Journalofveterinaryinternalmedicine,2013,27(5):1185-1192.ThyboNK,etal.Dose-dependenteffectsofperindoprilonbloodpressureandsmall-arterystructure[J].Hypertension,1994,23(5):659-666.JefferyTK,etal.Perindopril,anangiotensinconvertingenzymeinhibitor,inpulmonaryhypertensiverats:comparativeeffectsonpulmonaryvascularstructureandfunction.BrJPharmacol.1999Dec;128(7):1407-18.XiongF,etal.InhibitionofAAAinaratmodelbytreatmentwithACEIperindopril.JSurgRes.2014Jun1;189(1):166-73.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-379