Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemEPANendonuclease-IN-3Cat.No.:HY-174431分?式:C??H??F?N?O?S分?量:511.54作?靶點:InfluenzaVirus作?通路:Anti-infection儲存?式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY?物活性PANendonuclease-IN-3?種有效的PAN核酸內(nèi)切酶(PANendonuclease)抑制劑，作?于流感病毒聚合酶復(fù)合物的IC50為17.4nM。PANendonuclease-IN-3對PAN內(nèi)切酶具有強效抑制作?。PANendonuclease-IN-3對多種當(dāng)前不同的流感病毒毒株顯?出強?的抗病毒活性，同時在MDCK細(xì)胞中表現(xiàn)出極低的細(xì)胞毒性。PANendonuclease-IN-3在A/WSN/33感染的??模型中顯著抑制病毒復(fù)制[1]。體外研究PANendonuclease-IN-3(Compound39-(S))(1-10μM)exhibitsinfluenzaAVirus(IAV)polymeraseinhibitorypotencyinHEK-293TcellswithanIC50of17.4nM,whichiscomparableactivitytoBaloxavir(HY-109025A)(IC50=17.8nM)[1].PANendonuclease-IN-3(1-103nM)demonstratespotentinhibitoryactivitiesagainstPANendonucleasewithanIC50valueof41.8nM[1].PANendonuclease-IN-3(46μL/well,72h)demonstratesexceptionalantiviralactivitieswithanEC50valueof0.21nMinMadin-Darbycaninekidney(MDCK)celllines[1].體內(nèi)研究PANendonuclease-IN-3(20mg/kg,intranasaladministration,singledose)suppressesvirusreplicationinthelungsofA/WSN/33virus-infectedmice[1].AnimalModel:A/WSN/33infectionmodelinfemaleBALB/cmice(6-8weeksold)(1×105TCID50/mouse)Dosage:20mg/kgAdministration:IntranasaladministrationsingledoseResult:Inhibitedviralreplication.Maintainednormalalveolarstructureinthelungsfromtreatedmice.1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemEReducedinfiltrationinimmunecell.REFERENCES[1].LiuS,etal.DesignandSynthesisofPANEndonucleaseInhibitorsthroughSpirocyclizationStrategyagainstInfluenzaAVirus.JMedChem.2025Jun18.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792