Hotline:400-820-3792Inhibitors ? ScreeningLibraries ? Proteinswww.MedChemERostafuroxin(Standard)Cat.No.:HY-12283RCASNo.:156722-18-8分子式:C??H??O?分子量:374.51作用靶點:Na+/K+ATPase;RSV作用通路:MembraneTransporter/IonChannel;Anti-infection儲存方式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY生物活性Rostafuroxin(Standard）是Rostafuroxin的分析標準品。本產(chǎn)品用于研究及分析應(yīng)用。Rostafuroxin(PST2238)是一種洋地黃毒苷衍生物，一種口服有效的Na+,K+-ATPase(ATP1A1)抑制劑。Rostafuroxin與ATP1A1胞外域特異性結(jié)合，并阻斷呼吸道合胞病毒(RSV)觸發(fā)的EGFRTyr845磷酸化。Rostafuroxin具有抗高血壓和抗RSV活性。REFERENCESQuadriL,etal.17beta-(3-furyl)-5beta-androstane-3beta,14beta,17alpha-triol(PST2238).Averypotentantihypertensiveagentwithanovelmechanismofaction.JMedChem.1997May23;40(11):1561-4.FerrariP,etal.PST2238:AnewantihypertensivecompoundthatmodulatesNa,K-ATPaseingenetichypertension.JPharmacolExpTher.1999Mar;288(3):1074-83.MatthiasLingemann,etal.Thealpha-1subunitoftheNa+,K+-ATPase(ATP1A1)isrequiredformacropinocyticentryofrespiratorysyncytialvirus(RSV)inhumanrespiratoryepithelialcells.PLoSPathog.2019Aug5;15(8):e1007963.CamillaFWenceslau,etal.Rostafuroxinamelioratesendothelialdysfunctionandoxidativestressinresistancearteriesfromdeoxycorticosteroneacetate-salthypertensiverats:theroleofNa+,K+-ATPase/cSRCpathway.JHypertens.2014Mar;32(3):542-54.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792Fa