Hotline:400-820-3792Inhibitors ? ScreeningLibraries ? Proteinswww.MedChemEPerezoneCat.No.:HY-N15582CASNo.:3600-95-1分子式:C??H??O?分子量:248.32作用靶點(diǎn):Apoptosis作用通路:Apoptosis儲(chǔ)存方式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY生物活性 Perezone是一種倍半萜類苯醌，可在Acourtia物種的根中發(fā)現(xiàn)。Perezone能抑制白血病細(xì)胞系K-562和人神經(jīng)膠質(zhì)癌細(xì)胞U-251(IC50:6.83μM)的活性。Perezone可增加與細(xì)胞凋亡(Apoptosis)相關(guān)的caspase3、8和9基因的表達(dá)。Perezone具有抗氧化和抗炎活性[1][2][3][4][5]。REFERENCESGómez-SerranoG,etal.Time-dependentperezoneproductionindifferentculturesystemsofAcourtiacordata[J].CentralEuropeanJournalofBiology,2012,7:507-518.Escobedo-GonzálezRG,etal.Characterizationandcomparisonofperezonewithsomeanalogues.Experimentalandtheoreticalstudy[J].JournalofMolecularStructure,2015,1097:98-105.Estévez-CarmonaMM,etal.Perezoneanditsphenylglycinederivativeinducecytotoxicityviacaspasesonhumanglialcancercells.NatProdRes.2024Jun;38(11):1823-1833.ConcepciónLozadaM,etal.Synthesis,cytotoxicandantioxidantevaluationsofaminoderivativesfromperezone.BioorgMedChem.2012Sep1;20(17):5077-84.MartínezJ,etal.ComputationalCharacterizationofPerezone,IsoperezoneandtheirSulfur‐Derivatives:Anti‐inflammatoryActivity[J].ChemistrySelect,2019,4(45):13333-13346.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792Fax:0