Hotline:400-820-3792Inhibitors ? ScreeningLibraries ? Proteinswww.MedChemEGuanosine5'-diphosphatedisodiumsalt(Standard)Cat.No.:HY-113066ARCASNo.:7415-69-2分子式:C??H??N?Na?O??P?分子量:487.16作用靶點(diǎn):EndogenousMetabolite;PotassiumChannel作用通路:MetabolicEnzyme/Protease;MembraneTransporter/IonChannel儲(chǔ)存方式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY生物活性 Guanosine5'-diphosphate(disodiumsalt)(Standard）是Guanosine5'-diphosphate(disodiumsalt)的分析標(biāo)準(zhǔn)品。本產(chǎn)品用于研究及分析應(yīng)用。Guanosine5'-diphosphate(GDP)disodiumsalt是一種嘌呤核苷二磷酸，通過(guò)核酸外切酶的作用和核苷對(duì)鳥(niǎo)嘌呤的磷酸化作用相互轉(zhuǎn)化為鳥(niǎo)嘌呤。Guanosine5'-diphosphatedisodiumsalt可激活adenosine5'-triphosphate敏感的K+通道，并用于研究GTP酶的動(dòng)力學(xué)和特性，如與G蛋白偶聯(lián)受體(GPCR)相關(guān)的酶。Guanosine5'-diphosphatedisodiumsalt是一種有效的鐵調(diào)節(jié)劑，可阻斷鐵調(diào)素-鐵轉(zhuǎn)運(yùn)蛋白[Hepcidin(HY-P70400)-ferroportin]相互作用并調(diào)節(jié)IL-6/STAT-3通路。Guanosine5'-diphosphatedisodiumsalt水平升高與神經(jīng)系統(tǒng)疾病的發(fā)病機(jī)制有關(guān)。Guanosine5'-diphosphatedisodiumsalt可用于炎癥研究，如炎癥性貧血(AI)[1][2][3][4][5]。IC50&Target K+channel[1],endogenousmetabolite[2].REFERENCESAngmoS,etal.IdentificationofGuanosine5'-diphosphateasPotentialIronMobilizer:PreventingtheHepcidin-FerroportinInteractionandModulatingtheInterleukin-6/Stat-3Pathway.SciRep.2017Jan5;7:40097.SKajioka,etal.Guanosinediphosphateactivatesanadenosine5'-triphosphate-sensitiveK+channelintherabbitportalvein.JPhysiol.1991Dec;444:397-418.CiruelaF.Guanosinebehindthescene.JNeurochem.2013Aug;126(4):425-7.RajGV,etal.Guanosinephosphatebindingproteincoupledreceptorsinprostatecancer:areview.JUrol.2002Mar;167(3):1458-63.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;021-