Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemEZIKV-IN-3Cat.No.:HY-151446CASNo.:947699-46-9分?式:C??H??NO?分?量:587.75作?靶點:DNAMethyltransferase;VirusProtease作?通路:Epigenetics;Anti-infection儲存?式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY?物活性ZIKV-IN-3(compound5a)?種穿?蓮內酯衍?物,有效的ZIKVNS5甲轉移酶(MTase)抑制劑，其IC50值為18.34μM。ZIKV-IN-3抑制ZIKV的復制和感染。ZIKV-IN-3可?于寨卡病毒(ZIKV)的研究。IC50&TargetIC50:18.34μM(MTase)[1]體外研究ZIKV-IN-2(compound5a;0.08-50μM)inhibitsZIKV-inducedplaqueformationwithanEC50valueof0.76μMandhasanti-ZIKVeffectwithEC50valuesof0.48,0.37,and0.45μMforVero,Huh7andA549cells,respectively[1].ZIKV-IN-2(0.08-50μM;48h)inhibitstheexpressionofZIKVEproteinwithanEC50valueof0.38μMandinhibitsZIKVreplicationandinfection[1].ZIKV-IN-2(0.08-50μM;96h)haslowcytotoxicityinVero,Huh7andA549cells[1].Vero,Huh7andA549cells[1].CellViabilityAssay[1]CellLine:Vero,Huh7andA549cellsConcentration:0.08,0.4,2,10,and50μMIncubationTime:96hoursResult:ExhibitedlowcytotoxicitiestoVerocells,Huh7cellsandA549cellswithCC50>200μMtoallthreecelllines.WesternBlotAnalysis[1]1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemECellLine:VerocellsConcentration:0.08,0.4,2,10,and50μMIncubationTime:48hoursResult:InhibitedtheexpressionofZIKVEproteininadose-dependentmanner.REFERENCES[1].QianW,etal.DiscoveryofdehydroandrographolidederivativeswithC19hinderedetheraspotentanti-ZIKVagentswithinhibitoryactivitiestoMTaseofZIKVNS5.EurJMedChem.2022Aug27;243:114710.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;0