Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemEAntimicrobialagent-9Cat.No.:HY-151403分?式:C??H??N??分?量:803.06作?靶點(diǎn):Bacterial作?通路:Anti-infection儲(chǔ)存?式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY?物活性Antimicrobialagent-9(Compound16)?種抗劑(antimicrobial)，對?蘭?陽性和?蘭?性細(xì)的MIC范為2-8μg/mL。Antimicrobialagent-9也具有抗炎活性。體外研究Antimicrobialagent-9(Compound16)(0-256μg/mL;18-24h)showsantibacterialactivitywithgeometricmean(GM)valuesoftheMICsof4.5μg/mL[1].Antimicrobialagent-9showsminimumhemolyticconcentration(MHC)of>256μg/mL,thetherapeuticindexis113.8[1].Antimicrobialagent-9(5or20μg/mL;18h)effectivelyinhibitsthereleaseandexpressionofNOandTNF-αfromLPS-stimulatedRAW264.7cells[1].Antimicrobialagent-9isresistanttovariousphysiologicalsalts,humanserum,andproteases[1].Antimicrobialagent-9exhibitssynergisticantimicrobialactivityincombinationwiththreeconventionalantibiotics(Chloramphenicol(HY-B0239),Ciprofloxacin(HY-B0356),andoxacillin)againstMDRPAandMRSA,ispromisingadjuvantsincombinationwithclinicallyusedantibiotics[1].CellViabilityAssay[1]CellLine:E.coli[KCTC1682],P.aeruginosa[KCTC1637],S.epidermidis[KCTC1917]andS.aureus[KCTC1621]Concentration:0-256μg/mLIncubationTime:18-24hResult:InhibitedbacterialgrowthwithMICsof4,8,4and2μg/mLagainstE.coli[KCTC1682],P.aeruginosa[KCTC1637],S.epidermidis[KCTC1917]andS.aureus[KCTC1621],1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemErespectively.CellViabilityAssay[1]CellLine:LPS-stimulatedRAW264.7macrophagesConcentration:5μg/mL(forNO/iNOS)and20μg/mL(forTNF-α)IncubationTime:18hResult:EffectivelyinhibitedtheproductionandexpressionofNOandTNF-αfromLPS-stimulatedRAW264.7cells.REFERENCES[1].DineshKumarS,etal.Cationic,amphipathicsmallmoleculesbasedonatriazine-piperazine-triazinescaffoldasanewclassofantimicrobialagents.EurJMedChem.2022Sep8;243:114747.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.