Hotline:400-820-3792Inhibitors ? ScreeningLibraries ? Proteinswww.MedChemEPexidartinibhydrochloride(Standard)Cat.No.:HY-16749ARCASNo.:2040295-03-0分子式:C??H??Cl?F?N?分子量:454.28作用靶點(diǎn):c-Fms;c-Kit;Apoptosis作用通路:ProteinTyrosineKinase/RTK;Apoptosis儲(chǔ)存方式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY生物活性Pexidartinib(hydrochloride)(Standard)是Pexidartinib(hydrochloride)的分析標(biāo)準(zhǔn)品。本產(chǎn)品用于研究及分析應(yīng)用。Pexidartinibhydrochloride(PLX-3397hydrochloride)是一種有效、具有口服活性的，選擇性ATP-競(jìng)爭(zhēng)性的集落刺激因子1(CSF1R或M-CSFR)和c-Kit抑制劑，IC50值分別為20和1IC50&TargetIC50:10nM(c-Kit),20nM(cFMS),160nM(FLT3),350nM(KDR),860nM(LCK),880nM(FLT1),890nM(NTRK3)[1]REFERENCESDeNardoDG,etal.Leukocytecomplexitypredictsbreastcancersurvivalandfunctionallyregulatesresponsetochemotherapy.CancerDiscov.2011Jun;1(1):54-67.KuseY,etal.Microgliaincreasestheproliferationofretinalprecursorcellsduringpostnataldevelopment.MolVis.2018Jul30;24:536-545.eCollection2018.LeeJH,etal.AphaseIstudyofpexidartinib,acolony-stimulatingfactor1receptorinhibitor,inAsianpatientswithadvancedsolidtumors.InvestNewDrugs.2019Mar2.MerryTL,etal.TheCSF1receptorinhibitorpexidartinib(PLX3397)reducestissuemacrophagelevelswithoutaffectingglucosehomeostasisinmice.IntJObes(Lond).2020;44(1):245-253.LuoL,etal.Intermittenttheta-burststimulationimprovesmotorfunctionbyinhibitingneuronalpyroptosisandregulatingmicroglialpolarizationviaTLR4/NFκB/NLRP3signalingpathwayincerebralischemicmice.JNeuroinflammation.2022Jun11;19(1):141.ChadarevianJP,etal.Engineeringaninhibitor-resistanthumanCSF1Rvariantformicrogliareplacement.JExpMed.2023Mar6;220(3):e20220857.McePdfHeight1/1 MasterofBioactiveMolecules—您身邊的抑制劑大師www.MedChemECaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-