Hotline:400-820-3792Inhibitors ? ScreeningLibraries ? Proteinswww.MedChemEPaliperidonepalmitate(Standard)Cat.No.:HY-A0019ARCASNo.:199739-10-1分子式:C??H??FN?O?分子量:664.89作用靶點(diǎn):DopamineReceptor;5-HTReceptor作用通路:GPCR/GProtein;NeuronalSignaling儲(chǔ)存方式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY生物活性 Paliperidonepalmitate(Standard)是Paliperidonepalmitate的分析標(biāo)準(zhǔn)品。本產(chǎn)品用于研究及分析應(yīng)用。Paliperidonepalmitate是一種口服有效、可以通過血腦屏障的多巴胺D2受體和5-羥色胺2A(5-HT2A)受體的競(jìng)爭(zhēng)性拮抗劑。Paliperidonepalmitate通過與多巴胺D2受體和5-HT2A受體結(jié)合，競(jìng)爭(zhēng)性地抑制多巴胺和5-羥色胺的作用，調(diào)節(jié)神經(jīng)遞質(zhì)系統(tǒng)的平衡，從而發(fā)揮抗精神病活REFERENCESDarvilleN,etal.Theeffectofmacrophageandangiogenesisinhibitiononthedrugreleaseandabsorptionfromanintramuscularsustained-releasepaliperidonepalmitatesuspension.JControlRelease.2016May28;230:95-108.PertinezH,etal.Hyaluronidaseimpactsexposuresoflong-actinginjectablepaliperidonepalmitateinrodentmodels.bioRxiv[Preprint].2024Mar6:2024.03.03.583160.KwonJS,etal.Satisfactionofimmediateordelayedswitchtopaliperidonepalmitateinpatientsunsatisfiedwithcurrentoralatypicalantipsychotics.IntClinPsychopharmacol.2015;30(6):320-328.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792Fax:021-5370