Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemEUNC0638hydrateCat.No.:HY-110093CASNo.:1255517-77-1分?式:C??H??N?O?分?量:527.74作?靶點(diǎn):VSV;HistoneMethyltransferase;Autophagy;InfluenzaVirus作?通路:Anti-infection;Epigenetics;Autophagy儲存?式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY?物活性UNC0638hydrate選擇性抑制G9a和GLP組蛋?甲轉(zhuǎn)移酶，IC50分別為15nM和19nM。UNC0638hydrate在體外可抑制TNBC細(xì)胞的侵襲和遷移。UNC0638hydrate也EHMT1/2的抑制劑，在?紅細(xì)胞祖細(xì)胞培養(yǎng)中誘導(dǎo)胎??紅蛋?(HbF)表達(dá)。此外，UNC0638hydrate具有抗FMDV(?蹄疫病毒)和抗VSV(?性?炎病毒)的活性，對多種表觀遺傳和?表觀遺傳靶標(biāo)具有出?的效?和選擇性。IC50&TargetIC50:[1]戶使?本產(chǎn)品發(fā)表的科研?獻(xiàn)?ProcNatlAcadSciUSA.2019Feb19;116(8):2961-2966.?CellChemBiol.2022Jun18;S2451-9456(22)00198-2.?ActaPharmacolSin.2021Apr13.?CellDeathDis.2018Jan26;9(2):129.?CellBiosci.2023Jan12;13(1):7.Seemorecustomervalidationsonwww.MedChemEREFERENCES[1].VedadiM,etal.AchemicalprobeselectivelyinhibitsG9aandGLPmethyltransferaseactivityincells.NatChemBiol.2011Jul10;7(8):566-74.[2].FuL,etal.EffectsoftheHistoneMethyltransferaseInhibitorUNC0638onHistoneH3K9DimethylationofCulturedOvineSomaticCells1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemEandDevelopmentofResultingEarlyClonedEmbryos.ReprodDomestAnim.2014Apr;49(2):e21-5.[3].SinghN,etal.InhibitionofEHMT2InducesaRobustAntiviralResponseAgainstFoot-and-MouthDiseaseandVesicularStomatitis

VirusInfectionsinBovineCells.JInterferonCytokineRes.2016Jan;36(1):37-47.[4].LiuXR,etal.UNC0638,aG9ainhibitor,suppressesepithelial?mesenchymaltransition?mediatedcellularmigrationandinvasionintriplenegativebreastcancer[J].Molecularmedicinereports,2018,17(2):2239-2244.[5].NualkaewT,etal.UNC0638induceshighlevelsoffetalhemoglobinexpressioninβ-thalassemia/HbEerythroidprogenitorcells[J].Annalsofhematology,2020,99:2027-2036.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:4