Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemEPam2CysCat.No.:HY-165613CASNo.:656831-18-4Synonyms:Dipalmitoyl-S-glyceryl-cysteine;S-[2,3-Bis(palmitoyloxy)propyl]cysteine分?式:C??H??NO?S分?量:672.05作?靶點(diǎn):Toll-likeReceptor(TLR)作?通路:Immunology/Inflammation儲存?式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY?物活性Pam2Cys(Dipalmitoyl-S-glyceryl-cysteine;S-[2,3-Bis(palmitoyloxy)propyl]cysteine)樹突狀細(xì)胞TLR2的選擇性激動劑，靶向樹突狀細(xì)胞的脂質(zhì)部分。Pam2Cys通過靶向和激活樹突狀細(xì)胞發(fā)揮作?，從?誘導(dǎo)強(qiáng)烈的免疫反應(yīng)，例如特異性抗體的產(chǎn)?。Pam2Cys在不需外佐劑的情況下可增強(qiáng)免疫原性。Pam2Cys可應(yīng)?于疫研究，特別開發(fā)針對甲型流感病毒和其他病毒的脂肽疫以誘導(dǎo)保護(hù)性免疫反應(yīng)。IC50&TargetTLR2REFERENCES[1].PejoskiD,etal.AlipopeptidebasedontheM2andHAproteinsofinfluenzaAvirusesinducesprotectiveantibody.ImmunolCellBiol.2010Jul;88(5):605-11.[2].FranzoniG,etal.TargetingToll-LikeReceptor2:PolarizationofPorcineMacrophagesbyaMycoplasma-DerivedPam2cysLipopeptide.Vaccines(Basel).2021Jun23;9(7):692.[3].TanAC,etal.IntranasaladministrationoftheTLR2agonistPam2Cysprovidesrapidprotectionagainstinfluenzainmice.MolPharm.2012Sep4;9(9):2710-8.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792ax:021-537003