Hotline:400-820-3792Inhibitors ? ScreeningLibraries ? Proteinswww.MedChemEOsilodrostat(Standard)Cat.No.:HY-16276RCASNo.:928134-65-0分子式:C??H??FN?分子量:227.24作用靶點:MineralocorticoidReceptor作用通路:MetabolicEnzyme/Protease;VitaminDRelated/NuclearReceptor儲存方式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY生物活性Osilodrostat(Standard)是Osilodrostat的分析標準品。本產(chǎn)品用于研究及分析應用。Osilodrostat(LCI699)是一種口服有效的11β-羥化酶(CYP11B1)抑制劑，其IC50值為35nM。Osilodrostat是一種口服有效的醛固酮合成酶(CYP11B2)抑制劑，抑制人醛固酮合成酶和大鼠醛固酮合成酶的IC50分別為0.7nMIC50&TargetIC50:35nM(CYP11B1),0.7nM(humanaldosteronesynthase),and160nM(rataldosteronesynthase)[1][2]REFERENCESMénardJ,et,al.Aldosteronesynthaseinhibition:cardiorenalprotectioninanimaldiseasemodelsandtranslationofhormonaleffectstohumansubjects.JTranslMed.2014Dec10;12:340.CreemersSG,et,al.OsilodrostatIsaPotentialNovelSteroidogenesisInhibitorfortheTreatmentofCushingSyndrome:AnInVitroStudy.JClinEndocrinolMetab.2019Aug1;104(8):3437-3449.LiL,et,al.Osilodrostat(LCI699),apotent11β-hydroxylaseinhibitor,administeredincombinationwiththemultireceptor-targetedsomatostatinanalogpasireotide:A13-weekstudyinrats.ToxicolApplPharmacol.2015Aug1;286(3):224-33.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792Fax:02