Hotline:400-820-3792Inhibitors ? ScreeningLibraries ? Proteinswww.MedChemEKynurenicacidsodium(Standard)Cat.No.:HY-107512RCASNo.:2439-02-3分子式:C??H?NNaO?分子量:211.15作用靶點(diǎn):iGluR;Apoptosis;EndogenousMetabolite;CXCR;GPR35作用通路:MembraneTransporter/IonChannel;NeuronalSignaling;Apoptosis;MetabolicEnzyme/Protease;GPCR/GProtein;Immunology/Inflammation儲存方式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY生物活性Kynurenicacid(sodium)(Standard）是Kynurenicacid(sodium)的分析標(biāo)準(zhǔn)品。本產(chǎn)品用于研究及分析應(yīng)用。Kynurenicacidsodium是一種內(nèi)源性色氨酸代謝物，是針對靶點(diǎn)NMDA,glutamate,α7nicotinicacetylcholinereceptor的光譜性拮抗劑。Kynurenicacidsodium也是GPR35/CXCR8的激動劑。IC50&TargetTarget:GPR35[1],NMDA,glutamate,glutamate,α7nicotinicacetylcholine[2]REFERENCESWangJ,etal.KynurenicacidasaligandfororphanGprotein-coupledreceptorGPR35.JBiolChem.2006Aug4;281(31):22021-8.AlbuquerqueEX,etal.Kynurenicacidasanantagonistofα7nicotinicacetylcholinereceptorsinthebrain:factsandchallenges.BiochemPharmacol.2013Apr15;85(8):1027-32.Ma?aczewskaJ,etal.Effectoforaladministrationofkynurenicacidontheactivityoftheperipheralbloodleukocytesinmice.CentEurJImmunol.2014;39(1):6-13.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792Fax:021-5