Hotline:400-820-3792Inhibitors ? ScreeningLibraries ? Proteinswww.MedChemENilotinibhydrochloridedihydrateCat.No.:HY-10159CSynonyms: AMN107hydrochloridedihydrate分子式: C??H??ClF?N?O?分子量: 602.01作用靶點: Autophagy;Bcr-Abl作用通路: Autophagy;ProteinTyrosineKinase/RTK儲存方式: 4°C,sealedstorage,awayfrommoistureInsolvent:-80°C,6months;-20°C,1month(sealedstorage,awayfrommoisture)BIOLOGICALACTIVITY生物活性 Nilotinib(AMN107)hydrochloridedihydrate是一種口服可用的具有抗腫瘤活性的Bcr-Abl酪氨酸激酶抑制，可用于慢性骨髓性白血病的研究?？蛻羰褂帽井a(chǎn)品發(fā)表的科研文獻CellMolImmunol.2024Aug;21(8):856-872.SciTranslMed.2018Jul18;10(450).pii:eaaq1093.Biomaterials.16September2022.CancerRes.2024Oct22.CancerLett.2024Aug1:217150.Seemorecustomervalidationsonwww.MedChemEREFERENCESWeisbergE,etal.BeneficialeffectsofcombiningnilotinibandimatinibinpreclinicalmodelsofBCR-ABL+leukemias.Blood.2007Mar1;109(5):2112-20.SakoH,etal.AntitumoreffectofthetyrosinekinaseinhibitorNilotinibongastrointestinalstromaltumor(GIST)andImatinib-resistantGISTcells.PLoSOne.2014Sep15;9(9):e107613.MeirsonT,etal.Targetinginvadopodia-mediatedbreastcancermetastasisbyusingABLkinaseinhibitors.Oncotarget.2018Apr24;9(31):22158-22183.1/2 MasterofBioactiveMolecules—您身邊的抑制劑大師www.MedChemEMcePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792Fax:021