Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemEBetulin-d3-1Cat.No.:HY-N0083S2分?式:C??H??D?O?分?量:445.74作?靶點(diǎn):Isotope-LabeledCompounds;Apoptosis;FattyAcidSynthase(FASN);EndogenousMetabolite作?通路:Others;Apoptosis;MetabolicEnzyme/Protease儲(chǔ)存?式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY?物活性Betulin-d3-1Betulin(HY-N0083)的氘代物。Betulin?種SREBP抑制劑，在K562細(xì)胞中的IC50值14.5μM。體外研究Stableheavyisotopesofhydrogen,carbon,andotherelementshavebeenincorporatedintodrugmolecules,largelyastracersforquantitationduringthedrugdevelopmentprocess.Deuterationhasgainedattentionbecauseofitspotentialtoaffectthepharmacokineticandmetabolicprofilesofdrugs[1].REFERENCES[1].KrólSK,etal.Comprehensivereviewonbetulinasapotentanticanceragent.BiomedResInt.2015;2015:584189.[2].DragM,etal.ComparisionoftheCytotoxicEffectsofBirchBarkExtract,BetulinandBetulinicAcidTowardsHumanGastricCarcinomaandPancreaticCarcinomaDrug-sensitiveandDrug-ResistantCellLines.Molecules.2009Apr24;14(4):1639-51.[3].MaC,etal.Protectiveeffectofbetulinoncognitivedeclineinstreptozotocin(STZ)-induceddiabeticrats.Neurotoxicology.2016Dec;57:104-111.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792ax:021