Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemEGolgicideACat.No.:HY-100540CASNo.:1139889-93-2Synonyms:GCA分?式:C??H??F?N?分?量:284.3作?靶點(diǎn):Enterovirus作?通路:Anti-infection儲(chǔ)存?式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性數(shù)據(jù)體外實(shí)驗(yàn)DMSO:100mg/mL(351.74mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制備儲(chǔ)備液1mM3.5174mL17.5871mL35.1741mL5mM0.7035mL3.5174mL7.0348mL10mM0.3517mL1.7587mL3.5174mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；?旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。儲(chǔ)備液的保存?式和期限：-80°C,6months;-20°C,1month。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)?內(nèi)使?，-20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)?內(nèi)使?。體內(nèi)實(shí)驗(yàn)請(qǐng)根據(jù)您的實(shí)驗(yàn)動(dòng)物和給藥?式選擇適當(dāng)?shù)娜芙?案。以下溶解?案都請(qǐng)先按照InVitro?式配制澄的儲(chǔ)備液，再依次添加助溶劑：(為保證實(shí)驗(yàn)結(jié)果的可靠性，澄的儲(chǔ)備液可以根據(jù)儲(chǔ)存條件，適當(dāng)保存；體內(nèi)實(shí)驗(yàn)的?作液，建議您現(xiàn)?現(xiàn)配，當(dāng)天使?；以下溶劑前顯?的百分?指該溶劑在您配制終溶液中的體積占?；如在配制過(guò)程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過(guò)加熱和/或超聲的?式助溶)1.請(qǐng)依序添加每種溶劑：10%DMSO>>90%(20%SBE-β-CDinsaline)1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemESolubility:≥2.5mg/mL(8.79mM);Clearsolution2.請(qǐng)依序添加每種溶劑：10%DMSO>>90%cornoilSolubility:≥2.5mg/mL(8.79mM);ClearsolutionBIOLOGICALACTIVITY?物活性GolgicideA(GCA)?種有效的，?度特異性的，可逆的式?爾體ADP-核糖化因?鳥(niǎo)嘌呤核苷酸交換因?(ArfGEFGBF1)抑制劑。GolgicideA可抑制柯薩奇病毒B3(CVB3)和其他?類(lèi)腸道病毒的復(fù)制。IC50&TargetGBF1[1]體外研究GolgicideA(GCA)isapotentandhighlyeffectiveinhibitorofshigatoxinactivity.GolgicideA(GCA)inhibitstheeffectofshigatoxinonproteinsynthesiswithanIC50of3.3μM[1].戶(hù)使?本產(chǎn)品發(fā)表的科研?獻(xiàn)?MolMetab.2021Dec;54:101329.Seemorecustomervalidationsonwww.MedChemEREFERENCES[1].SáenzJB,etal.GolgicideArevealsessentialrolesforGBF1inGolgiassemblyandfunction.NatChemBiol.2009Mar;5(3):157-65.[2].vanderLindenL,etal.DifferentialeffectsoftheputativeGBF1inhibitorsGolgicideAandAG1478onenterovirusreplication.JVirol.2010Aug;84(15):7535-42.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3