Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemEDiMNFCat.No.:HY-103222CASNo.:14756-24-2Synonyms:3',4'-Dimethoxy-αNF分?式:C??H??O?分?量:332.35作?靶點:ArylHydrocarbonReceptor作?通路:Immunology/Inflammation儲存?式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性數(shù)據(jù)體外實驗DMSO:12.5mg/mL(37.61mM;ultrasonicandwarmingandheatto70°C)MassSolvent1mg5mg10mgConcentration制備儲備液1mM3.0089mL15.0444mL30.0888mL5mM0.6018mL3.0089mL6.0178mL10mM0.3009mL1.5044mL3.0089mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；?旦配成溶液，請分裝保存，避免反復凍融造成的產(chǎn)品失效。儲備液的保存?式和期限：-80°C,6months;-20°C,1month。-80°C儲存時，請在6個?內(nèi)使?，-20°C儲存時，請在1個?內(nèi)使?。BIOLOGICALACTIVITY?物活性DiMNF(3',4'-Dimethoxy-αNF)?種選擇性芳烴受體(AHR)調(diào)節(jié)劑。DiMNF?種具有明顯拮抗活性的競爭性AHR配體(IC50=21nM)。DiMNF可?作抗炎劑。體外研究DiMNF(3',4'-Dimethoxy-αNF)(10μM;4h)minimallyinfluencesAHRgenebattery[1].1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemEDiMNF(10μM;1h)effectivelysuppressescytokine-mediatedinflammatorygeneexpression[1].DiMNFadoptsauniqueorientationwithintheligandbindingpocketofAHR[1].RT-PCR[1]CellLine:Huh7cellConcentration:10μMIncubationTime:4hor1hResult:DecreasedCYP1A1mRNAexpression(4h).Exhibitedrepressiveactivitytowardcytokine-mediatedSAA1induction(1h).SignificantlyreducedIL1β-mediatedmRNAinductionofC4,C1S,C1R,andC3.REFERENCES[1].MurrayIA,etal.Suppressionofcytokine-mediatedcomplementfactorgeneexpressionthroughselectiveactivationoftheAhreceptorwith3',4'-dimethoxy-α-naphthoflavone.MolPharmacol.2011Mar;79(3):508-19.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;021-5