Hotline:400-820-3792Inhibitors ? ScreeningLibraries ? Proteinswww.MedChemE(±)-DesisopropylpropranololCat.No.:HY-W192276CASNo.:20862-11-7Synonyms:N-Desisopropylpropranolol分子式:C??H??NO?分子量:217.26作用靶點:DrugMetabolite;AdrenergicReceptor作用通路:MetabolicEnzyme/Protease;GPCR/GProtein;NeuronalSignaling儲存方式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY生物活性(±)-Desisopropylpropranolol(N-Desisopropylpropranolol)是Propranolol(HY-B0573B)的代謝物。Propranolol是一種非選擇性β-腎上腺素受體(βAR)拮抗劑，對β1AR和β2AR具有高親和力，Ki分別為1.8nM和0.8nM。Propranolol抑制[3H]-DHA與大鼠腦膜制劑的結(jié)合，IC50為12nM。Propranolol用于高血壓、嗜鉻細(xì)胞瘤、心肌梗死、心律失常、心絞痛和肥厚型心肌病的相關(guān)研究[1][2][3][4]。IC50&TargetβadrenergicreceptorREFERENCESGalandrinS,etal.Distinctsignalingprofilesofbeta1andbeta2adrenergicreceptorligandstowardadenylylcyclaseandmitogen-activatedproteinkinaserevealsthepluridimensionalityofefficacy.MolPharmacol.2006Nov;70(5):1575-84.BrileyM,etal.Evidenceagainstbeta-adrenoceptorblockingactivityofdiltiazem,adrugwithcalciumantagonistproperties.BrJPharmacol.1980Aug;69(4):669-73.Al-MajedAA,etal.Propranolol.ProfilesDrugSubstExcipRelatMethodol.2017;42:287-338.ZHAOL,etal.LC/MS/MSdeterminationofpropranololanditsmetabolites4-hydroxypropranololandN-desisopropylpropranololinratplasma[J].ChineseJournalofPharmaceuticalAnalysis,2005,25(10):1203-1206.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792F