Hotline:400-820-3792Inhibitors ? ScreeningLibraries ? Proteinswww.MedChemEIpidacrine-d9Cat.No.:HY-W027553S1Synonyms:NIK-247-d10freebase分子式:C??H?D??N?分子量:198.33作用靶點:Isotope-LabeledCompounds;Cholinesterase(ChE);PotassiumChannel;SodiumChannel作用通路:Others;NeuronalSignaling;MembraneTransporter/IonChannel儲存方式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY生物活性Ipidacrine-d9(NIK-247-d9(freebase))是Ipidacrine(HY-W027553)的氘代物。Ipidacrine是一種口服有效和腦滲透性的AChE和BuChE抑制劑，IC50為1μM和1.9μM。Ipidacrine也是M2-cholinergicreceptors的部分激動劑，具有可逆的cholinesterase抑制作用。Ipidacrine能刺激神經肌肉傳遞，具有適度鎮(zhèn)痛效果。Ipidacrine與Tacrine(HY-111338)結構類似。Ipidacrine對各種遺忘模型有效，并能改善糖尿病大鼠的勃起功能，抑制神經元膜的K+andNa+-channels通道。Ipidacrine有望用于阿爾茨海默病、缺血性中風、面神經病、糖尿病性勃起功能障礙等研究[1][2][3][4][5]。體外研究Stableheavyisotopesofhydrogen,carbon,andotherelementshavebeenincorporatedintodrugmolecules,largelyastracersforquantitationduringthedrugdevelopmentprocess.Deuterationhasgainedattentionbecauseofitspotentialtoaffectthepharmacokineticandmetabolicprofilesofdrugs[1].REFERENCESKojimaJ,etal.Ipidacrine(NIK-247):AReviewofMultipleMechanismsasanAntidementiaAgent[J].CNSDrugReviews,1998,4(3):247-259.PulatovSS.Efficacyofipidacrineintherecoveryperiodofischaemicstroke[J].WorldBulletinofPublicHealth,2022,7:28-32.BykovV,etal.Ipidacrine(Axamon),AReversibleCholinesteraseInhibitor,ImprovesErectileFunctioninMaleRatsWithDiabetesMellitus-InducedErectileDysfunction[J].SexMed.2022Feb;10(1):100477.ZinovyevaOE,etal.Ipidacrineefficacyindiabeticpolyneuropathycomplextreatment:Areview[J].ConsiliumMedicum,2022,24(2):123-127.SamartsevIN,etal.Theefficacyandsafetyofipidacrineinpatientswithidiopathicneuropathyofthefacialnerve(PELICANstudy)[J].1/2 MasterofBioactiveMolecules—您身邊的抑制劑大師www.MedChemENeurology,Neuropsychiatry,Psychosomatics,2022,14(1):60-68.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel: